Foundation Science of Exosomes Book

Biogenesis, Characterization, Clinical Translation and Regenerative Applications

Authors: Dr. Leroy Rebello | Dr. Sreesudha Chepyala | Dr. Pratiksha Palahe
Publisher: Biotex Life Solutions Pvt Ltd | 190 Pages | Published: May 2026

A comprehensive scientific textbook on extracellular vesicle biology - covering the 
complete spectrum from molecular mechanisms to clinical translation. Written for 
postgraduate students, clinicians, researchers, and biotechnology professionals in 
regenerative medicine, diagnostics, and biomedical product development.

What This Book Covers:

Chapter 1 – What Exosomes Are and Why They Matter
Structural anatomy, lipidomic membrane dynamics, extracellular particle classification

Chapter 2 – Historical Evolution of Exosome Biology
From platelet dust to MISEV2023 guidelines and modern translational kits

Chapter 3 – Biogenesis and Secretion of Exosomes
ESCRT pathways, MVB formation, intraluminal vesicle release mechanisms

Chapter 4 – Cargo Sorting, Molecular Packaging, and Composition
Proteins, RNA, DNA, lipids, post-translational modifications, proteomics

Chapter 5 – Isolation, Enrichment, Characterization, and Quality Control
Pre-analytics, orthogonal characterization, functional assays, MISEV2018/2023 standards

Chapter 6 – Biodistribution and Routes of Administration
Organotropism, integrin code, blood-brain barrier, therapeutic design implications

Chapter 7 – Exosomes in Normal Physiology
Hematopoiesis, CNS, cardiovascular, reproductive biology, stem cell niches

Chapter 8 – Disease Biology and Regenerative Applications
Cancer, neurodegeneration, inflammation, wound healing, MSC-derived exosome therapy

Chapter 9 – Diagnostics, Therapeutic Engineering, and Regulatory Translation
Liquid biopsy, therapeutic engineering, GMP manufacturing, FDA/EMA regulatory pathways

Foreword by Dr. Pratiksha Palahe
Chief Scientific Officer, Biotex Life Solutions Pvt Ltd, Telangana, Bharat

Aligned with MISEV2018 and MISEV2023 guidelines of the International Society 
for Extracellular Vesicles (ISEV).